Good topic and good discussion here and something I have been pondering lately. Being a lefty, I am used to limited selections, however, I don't think there is a more limited selection than high lofted lefty drivers. Lefty drivers over 10.5 are few and far between.
Not really... get an adjustable driver that is 10.5* (aka titleist 910 series or the R11 series) and you can adjust them higher than 10.5*.